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 Table of Contents  
ORIGINAL ARTICLE
Year : 2015  |  Volume : 128  |  Issue : 2  |  Page : 226-232

Early Detection of Regional and Global Left Ventricular Myocardial Function Using Strain and Strain-rate Imaging in Patients with Metabolic Syndrome


1 Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling Related Cardiovascular Diseases, Ministry of Education, Beijing 100029; Department of Echocardiography in Heart Center, General Hospital of Ningxia Medical University, Ningxia, Yinchuan 750004, China
2 Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling Related Cardiovascular Diseases, Ministry of Education, Beijing 100029, China
3 Department of Echocardiography in Heart Center, General Hospital of Ningxia Medical University, Ningxia, Yinchuan 750004, China

Date of Submission12-Sep-2014
Date of Web Publication13-Jan-2015

Correspondence Address:
Ya Yang
Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling Related Cardiovascular Diseases, Ministry of Education, Beijing 100029
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.149211

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  Abstract 

Background: Strain and strain-rate imaging (SRI) have been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early subclinical changes in various pathologies. The aim of this study was to evaluate the regional and global left ventricular (LV) myocardial function in metabolic syndrome (MS) with SRI so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function.
Methods: Thirty-nine adults with MS were enrolled in the study. There was a control group of 39 healthy adults. In addition to classic echocardiographic assessment of LV global functional changes, SRI was used to evaluate regional and global LV function. Including: Peak systolic strain (S), peak systolic strain-rate (SR-s), peak diastolic strain-rate (SR-e).
Results: There were no statistically significant differences between MS and controls in all traditional parameters of LV systolic function. On the other hand, significant differences were observed between MS and the control group in most of the parameters of S, SR-s, SR-e in regional LV function. Multiple stepwise regression analyses revealed that S and SR significantly were negatively correlated with blood pressure, waist circumference, fasting plasma glucose, uric acid, suggesting that risk factories were relevant to regional systolic dysfunction.
Conclusion: In MS with normal LV ejection fraction, there was regional myocardial dysfunction, risk factors contributed to the impairment of systolic and diastolic function of the regional myocardium. Assessment of myocardial function using SRI could be more accurate in MS patient evaluation than conventional echocardiography alone.

Keywords: Metabolic Syndrome; Regional Left Ventricular Function; Strain and Strain-rate Imaging


How to cite this article:
Wang Q, Sun QW, Wu D, Yang MW, Li RJ, Jiang B, Yang J, Li ZA, Wang Y, Yang Y. Early Detection of Regional and Global Left Ventricular Myocardial Function Using Strain and Strain-rate Imaging in Patients with Metabolic Syndrome . Chin Med J 2015;128:226-32

How to cite this URL:
Wang Q, Sun QW, Wu D, Yang MW, Li RJ, Jiang B, Yang J, Li ZA, Wang Y, Yang Y. Early Detection of Regional and Global Left Ventricular Myocardial Function Using Strain and Strain-rate Imaging in Patients with Metabolic Syndrome . Chin Med J [serial online] 2015 [cited 2018 Jul 20];128:226-32. Available from: http://www.cmj.org/text.asp?2015/128/2/226/149211


  Introduction Top


Metabolic syndrome (MS) is a condition characterized by the accumulation of multiple risk factors (insulin resistance, hyperglycemia, dyslipidemia, hypertension, visceral obesity) for cardiovascular disease in an individual with a background of obesity and/or lack of exercise. [1] Even more with the change of the modern lifestyle and diet structure, incidence of MS increased year by year, it is greatly endangering people's health. However, it is not known whether MS is also associated with abnormal cardiac function. If MS indicates persons who have already developed abnormal left ventricular (LV) function, early recognition of MS would be important. Several studies have shown that sub-clinical diastolic dysfunction is evident in most patients with obesity and MS with either increased or no interval change in LV systolic function at rest. A study by Sasso et al. [2] demonstrated a reduced increase in ejection fraction (EF) in obese subjects during dynamic exercise using radionuclide ventriculography; however, [3] EF is a load-dependent measurement of systolic function that may not accurately reflect the subtle changes of early myocardial dysfunction.

Strain and strain-rate imaging (SRI) are a new noninvasive method for assessment of myocardial function. SRI has been found clinically useful in the assessment of cardiac systolic and diastolic function as well as providing new insights in deciphering cardiac physiology and mechanics in cardiomyopathies, and identifying early sub-clinical changes in various pathologies. Due to its ability to differentiate between active and passive movement of myocardial segments, to quantify components of myocardial function, such as longitudinal myocardial shortening, that are not visually assess-able, it allows comprehensive assessment of myocardial function and the spectrum of potential clinical applications is very wide. Strain (S) and strain-rate (SR) data are helpful for therapeutic decisions and also useful for follow-up evaluations of therapeutic results in cardiology. S and SR data also provide valuable prognostic information, especially prediction of future reverse remodeling in myocardial small lesions. [4],[5] Moreover, it seems that the regional dysfunction can be detected earlier than global dysfunction. [6]

The review explains the fundamental concepts of deformation imaging, describes in a comparative manner the two major deformation imaging methods (tissue Doppler imaging [TDI]-derived and two-dimensional [2D] speckle tracking, 2D-strain derived). Stefani et al. [7] reported that the strain can be computed in athletes by both TDI-derived and 2D-strain derived methods. The goal of our study was to assess LV regional function in patients with MS by TDI-derived imaging methods so that we can provide more myocardial small lesions in patients with MS, which is robust and reliable basis for early detection of LV function.


  Methods Top


Subjects and methodology

Thirty-nine adults with MS were enrolled in the study. All were recruited from the out-patient cardiology, diabetes and general medicine clinics of General Hospital of Ningxia Medical University from December 2010 to August 2012. Thirty-nine healthy adults with no MS and matched for age and gender comprised the control group. A diagnosis of MS was assigned according to the International Diabetes Federation in 2005 which is fit for Asians MS diagnostic criteria: Waist circumference (W. circum.) 90/80 cm (men/women) plus any two of the following four factors: Increased triglyceride level l150 mg/dL or a specific treatment for this lipid abnormality; reduced high-density lipoprotein cholesterol <40/50 mg/dL (men/women) or a treatment specific for this lipid abnormality; raised blood pressure (BP): Systolic BP (SBP) ≥130 or diastolic BP (DBP) ≥85 mmHg or treatment of previously diagnosed hypertension; raised fasting plasma glucose (FPG) ≥100 mg/dL or treatment of previously diagnosed type two diabetes. [8],[9]

Exclusion criteria were the following: Chronic kidney disease; a history or findings of cardiovascular disease including heart failure symptoms or systolic dysfunction; coronary artery disease (through exercise testing); significant valvular heart disease (i.e., greater than mild valvular insufficiency, or stenosis) and/or hypertrophic cardiomyopathy; pregnancy or lactation; and/or major systemic illness.

All groups had a full medical history and clinical examination including BP measurement, anthropometric measures, systemic examination, biochemical tests including lipid profile, FPG and echocardiographic studies. W. circum., a validated estimate of visceral adiposity, was measured to the nearest 0.5 cm. [10] Systemic hypertension was defined according to the Joint National Committee VII criteria, as a BP > 140/90 mmHg and/or under current antihypertensive therapy. [11]

Echocardiographic evaluation M-mode and 2D echocardiographic studies were performed with a GE phased array ultrasonoscope (VIVID-7 dimension, USA) using a 3.5 MHz transducer.

Parameters of left ventricular structure

Left ventricular dimensions (systolic diameter and diastolic diameter) were measured at end diastole (R wave of electrocardiogram) and end systole (maximum posterior motion of septum) and were indicated by d and s, respectively. All were detected in the parasternal long-axis view during M-mode tracing according to the recommendation of the American Society of echocardiography. [12]

Parameters of systolic function

Left ventricular end-diastolic and end-systolic volumes (EDV and ESV) were calculated according to Abraham et al.; stroke volume was calculated as the difference between EDV and ESV; EF was calculated as EF% =100 × (EDV − ESV)/EDV.

Parameters of diastolic function

Assessment of diastolic function was obtained by pulsed-wave Doppler of transmitral flow patterns recorded in the apical four-chamber view where the sample volume was best positioned in the LV at the tips of the valve leaflets. Mitral flow early-phase filling velocity (E), peak atrial phase filling velocity (A), and E/A ratio were measured.

Parameters of strain-rate imaging

Myocardial S and SR was derived from TDI. S and SR were derived from S and SR curves [13] obtained by placing a sample bar (10 mm) in the basal and middle segments of the septal, lateral, inferior, anterior and posterior walls from the apical four-chamber [Figure 1], two-chamber and long axis views. S and SR curves were extracted from color TDI by standard software (GE Vingmed). SR data were recorded from the basal and middle segments, using standard apical views at a high frame rate (>100 frames/s). The region of interest [Figure 2] inter-ventricular septum was constant at 5 mm 2 during the whole trial and was tracked automatically throughout the systole. The basal and mid-myocardial layer were sampled in each segment and maintained at the same position during the cardiac cycle by manually tracking wall motion [Figure 2], but we excluded data if we were unable to obtain a smooth strain curve or the angle between the scan line and wall was >20°. Peak systolic strain was defined as the greatest value on the strain curve, and peak systolic strain-rate (SR-s) was measured from the strain curve as previously validated. At the same time SR-s, peak early and late diastolic strain-rate (SR-e and SR-a), and peak systolic strain from the same sample volume within the same cardiac cycle. SR data were averaged from 4 to 6 cycles. [14]
Figure 1: Cardiac segments examined with strain-rate imaging.

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Figure 2: Strain and strain-rate imaging from the mid-inferoseptal myocardial segment from a study subject. Peak systolic strain is the peak percentage long-axis shortening; peak systolic strain-rate is the peak rate of shortening; peak diastolic strain-rate is the peak rate of length.

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Peak systolic strain-rate represents the maximal rate of deformation in systole, systolic strain represents the magnitude of deformation between end diastole used as a reference point and end systole.

Ethics

Informed consent was obtained from all adults. The aim and the value of the work were explained in a simplified manner for them. There was no harm inflicted on them. The study was approved by the Ethics Committee of Faculty of General Hospital of Ningxia Medical University.

Statistical analysis

The analysis was carried out by a computer program (SPSS Version 17, SPSS Inc., IL, USA). Descriptive data are reported as mean ± standard deviation. According to the type of data, the Student's unpaired t-test was used for statistical comparisons between two groups. The P value was set at <0.05 for statistically significant results. Multiple regression analysis was utilized to assess the relationships between risk factories and S or SR. To determine the reproducibility of the S and SR derived from TDI, S and SR analyses of ten subjects were repeated by an additional investigator and by the same primary reader 1 day later. During these repeated analyses, the investigators were blinded to the results of both prior measurements.


  Results Top


No significant difference was observed among the groups regarding age, sex, heart rate in [Table 1]. There were significant differences in W. circum., BP, FPG, cholesterol, low density lipoprotein, uric acid (UA) and triglycerides between MS and the control groups.
Table 1: Clinical and biochemical characteristics of MS and control groups


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Echocardiographic Doppler data are shown in [Table 2]. There were no statistically significant differences between MS and controls in all parameters of LV structural and systolic function exclude diastolic function.
Table 2: Conventional echocardiographic data in MS and control groups


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Strain and SR date were possible in 100% of the 900 attempted segments from the 78 echocardiographic studies with technically adequate images. S and SR data shown in [Table 3]. Compared with controls, patients with MS had significantly impaired resting S (P < 0.000) and SR-s (P < 0.000), SR-e (P < 0.000), SR-a (P < 0.05).
Table 3: Strain and strain - rate data in MS and control groups


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In multiple regression analysis, regarding the separate contribution to mid-aivs longitudinal peak strain in the four-chamber view of each parameter among all risk factors selected, SBP, DBP, W. circum., FPG, UA, were found to be significantly negatively related with S and SR [Table 4].
Table 4: Multiple regression analysis of association with between strain and strain - rate and risk factors


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Scheme showing the interrelations between MS and cardiovascular disease via complex reactions and endothelial dysfunction. These induce vascular stiffness and increased myocardial oxygen consumption in spite of down-regulated per-fusion. This unfavorable constellation results in cardiomyocyte stress (S and SR declined) and myocardial dysfunction as the first stage of diabetic cardiomyopathy.


  Discussion Top


Metabolic syndrome and left ventricular function

In the strong heart study, MS was found to be associated with reduced LV systolic and diastolic function and LV dimensions, while LV mass and relative wall thickness were found to be higher in the MS group. [15] Ahn et al. [16] reported that W. circum. was found to have the most significant effect on LV functional and geometric change. The latter is corroborated by the improvement in diastolic function with improvement in metabolic control of diabetes by specific medical therapy or lifestyle modification. Accordingly, diastolic dysfunction reflects the structural and metabolic milieu in the myocardium, and may allow targeted therapeutic interventions to modulate cardiac metabolism to prevent heart failure in insulin resistance and diabetes. [17]

In our study, we found functional modifications of the LV in patients with MS including diastolic and systolic function. In the current study, even in the isolated metabolic group who were nondiabetic and nonhypertensive and had a body mass index (BMI) significantly lower than the MS group, the altered global ventricular performance may be mediated by other potential mechanisms. This may contribute to insulin resistance [Figure 3], hypertriglyceridemia with subsequent impaired endothelial dysfunction, abnormalities in myocardial per fusion and/or metabolic substrate utilization, inflammation and oxidative stress, interstitial fibrosis, impaired ventricular - vascular interaction, etc. In conclusion, the current study shows that MS groups have an associated abnormal LV global performance.
Figure 3: The interrelations between metabolic syndrome and cardiovascular disease.

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Strain and strain-rate data compared to traditional echocardiographic parameters

Strain and SR are less affected by passive myocardial motion and tend to be uniform throughout the LV in normal subjects. These noninvasive techniques are rapidly evolving and expanding. Strain values enable the differentiation of normal from abnormal contraction in the ischemic myocardium. [18] The high sensitivity of longitudinal strain to detect functional impairment due to subtle ischemia could be explained by the predominant longitudinal orientation of subendocardial fibers, which are more susceptible to ischemia. [19],[20]

Tissue Doppler imaging associated with SRI [21] has shown its value in early detection of MS, and a measurable SR depression has been regarded as the earliest sign of LV regional systolic dysfunction in patients with MS long before a clinical manifestation of heart failure. Our study also showed that a subtle systolic decline of the SR appeared in MS, but the LV ejection fraction remained unchanged in the MS groups. Longitudinal fibers, as a consequence of their prominent subendocardial location, are more vulnerable to fibrosis and hemodynamic overload. Thus, subendocardial long-axis function may be impaired long before circular fiber dysfunction develops in the mid-wall or radial fiber dysfunction in the subepicardial layers. Consequently, subendocardial long-axis function is viewed as a potential marker of subclinical LV dysfunction in several disease conditions. Similarly, longitudinal fibers are more susceptible to ischemia than radial fibers. Thus, there appears to be an entire spectrum of systolic function abnormalities, ranging from normal systolic heart function to systolic heart failure, with heart failure with normal EF being located in between.

Left ventricular EF was the main parameter to describe global heart function. However, new features of echocardiography S and SR provide precise information especially of regional myocardial function. [22] The EF is the traditional measure of systolic LV function and has proved to be a strong predictor of clinical outcome in dilated cardiomyopathy and a variety of cardiac diseases. [23] The EF bears a curvilinear relationship with EDV and an inverse correlation with after load. [23] However, normalization by EDV makes it insensitive to sub clinical myocardial dysfunction in the normal-sized heart or the small hypertrophied ventricle. The normal-sized heart of patients with MS and correspondingly overweight body habits frequently results in poor delineation of the endocardial borders, which are prerequisites for the quantitative assessment of EF. Similarly, the traditional measurements of diastolic function, the Doppler-derived mitral valve inflow velocity pattern and its derivatives, have proved difficult to interpret because of the pseudo normal pattern, that defines grade two dysfunction, but may be mistaken for the normal pattern. [24] While other traditional Doppler echocardiographic parameters enable only semi quantitative assessment of diastolic function and cannot reliably distinguish perturbations in loading conditions from altered diastolic functions, SRI enables detailed quantification of global and regional diastolic function.

Strain and strain-rate in metabolic syndrome

Increased myocardial stiffness and reduce myocardial deformation ability, S and SR will reduce. In our study, S and SR were all declined in MS [Table 3], while the papillary muscle level of the S and SR were higher than those of the mitral level [Figure 4]. So there were regional myocardial dysfunctions in patients with MS. The impact of sub-clinical cardiac involvement in MS remains to be assessed . MS may have decreases of myocardial systolic and early diastolic velocities on TDI, even if they appear to have normal systolic and diastolic function on conventional echocardiography. [25]

Our multiple regression analysis, regarding the separate contribution to S and SR of each parameter among all risk factors selected, BP, W. circum., FPG, UA were found to significantly negatively related with S and SR [Table 4]. Increased relative risk of LV hypertrophy due to the presence of MS, once excluded age and BP, seems mediated mainly by BMI (as an index of increased adiposity), which works as both a hemodynamic and nonhemodynamic factor. [26],[27] The amount of lipid stored in ectopic depots in MS is directly correlated and that pericardium lipid in particular appeared correlated to cardiac function in a site-specific manner that appeared independent of insulin resistance and BMI. [28] One possibility is that pericardia lipid itself exerts a restrictive pressure on myocardial expansion in diastole, and thereby slightly reduces cardiac diastolic filling, and thus affects cardiac output. Another possibility is that pericardia lipid elaborates signaling molecules that affect cardiac function via direct venous drainage, and in this way affects diastolic function. [29] All these small changes cannot be found by traditional echocardiographic parameters, while SRI can detect easily. Irregular distribution of systolic S and SR induces in the LV segments may indicate that MS leads to heterogeneous myocardial involvement also in the early period. [30]
Figure 4: Strain and strain-rate imaging from the basal and mid myocardial segments from a study subject.

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Limitations

As with flow Doppler, TDI-derived imaging methods are angle dependent. With the currently available technology, SR has a relatively poor signal to noise ratio and is load sensitive. S measurements are made along a single ultrasound scan line.


  Conclusions Top


Strain and SR derived from SRI reflect an improved assessment of myocardial contraction and quantification of regional myocardial deformation in humans. [31] Particularly in the clinical setting, cardiovascular risk factors contributing to altered SRI measures occur before the development of global LV dysfunction. [32] In addition, the technology's allure lies primarily in its portability, relative affordability, widespread availability, noninvasive nature, and rapid real-time imaging capabilities. [33] SRI should be used routinely and become a standard research tool for MS.

 
  References Top

1.
Sliem H, Nasr G, Ibrahiem D. Global left ventricular performance in non-diabetic non-hypertensive metabolic syndrome adults. World J Cardiol 2011;3:48-53.  Back to cited text no. 1
[PUBMED]    
2.
Sasso FC, Carbonara O, Nasti R, Marfella R, Esposito K, Rambaldi P, et al. Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects. Eur Heart J 2005;26:1205-12.  Back to cited text no. 2
[PUBMED]    
3.
Ha TH, Seo HS, Choo WJ, Choi J, Suh J, Cho YH, et al. The effect of metabolic syndrome on myocardial contractile reserve during exercise in non-diabetic hypertensive subjects. J Cardiovasc Ultrasound 2011;19:176-82.  Back to cited text no. 3
[PUBMED]    
4.
Dandel M, Lehmkuhl H, Knosalla C, Suramelashvili N, Hetzer R. Strain and strain rate imaging by echocardiography - Basic concepts and clinical applicability. Curr Cardiol Rev 2009;5:133-48.  Back to cited text no. 4
[PUBMED]    
5.
Hwang JW, Kang SJ, Lim HS, Choi BJ, Choi SY, Hwang GS, et al. Impact of arterial stiffness on regional myocardial function assessed by speckle tracking echocardiography in patients with hypertension. J Cardiovasc Ultrasound 2012;20:90-6.  Back to cited text no. 5
[PUBMED]    
6.
D'hooge J, Heimdal A, Jamal F, Kukulski T, Bijnens B, Rademakers F, et al. Regional strain and strain rate measurements by cardiac ultrasound: Principles, implementation and limitations. Eur J Echocardiogr 2000;1:154-70.  Back to cited text no. 6
[PUBMED]    
7.
Stefani L, Toncelli L, Gianassi M, Manetti P, Di Tante V, Vono MR, et al. Two-dimensional tracking and TDI are consistent methods for evaluating myocardial longitudinal peak strain in left and right ventricle basal segments in athletes. Cardiovasc Ultrasound 2007;5:7.  Back to cited text no. 7
[PUBMED]    
8.
Balkau B, Valensi P, Eschwège E, Slama G. A review of the metabolic syndrome. Diabetes Metab 2007;33:405-13.  Back to cited text no. 8
    
9.
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome - A new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med 2006;23:469-80.  Back to cited text no. 9
[PUBMED]    
10.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: An American heart association/national heart, lung, and blood institute scientific statement. Circulation 2005;112:2735-52.  Back to cited text no. 10
[PUBMED]    
11.
The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med 1997;157:2413-46.  Back to cited text no. 11
    
12.
Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials: A report from the American Society of Echocardiography guidelines and standards committee and the task force on echocardiography in clinical trials. J Am Soc Echocardiogr 2004;17:1086-119.  Back to cited text no. 12
    
13.
Pellerin D, Sharma R, Elliott P, Veyrat C. Tissue Doppler, strain, and strain rate imaging for the assessment of left and right systolic ventricular function. Heart 2003;89 Suppl III: iii9-17.  Back to cited text no. 13
    
14.
Zhang H, Shen WS, Gao CH, Deng LC, Shen D. Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer. Drugs R D 2012;12:101-6.  Back to cited text no. 14
[PUBMED]    
15.
Chinali M, de Simone G, Roman MJ, Best LG, Lee ET, Russell M, et al. Cardiac markers of pre-clinical disease in adolescents with the metabolic syndrome: The strong heart study. J Am Coll Cardiol 2008;52:932-8.  Back to cited text no. 15
[PUBMED]    
16.
Ahn MS, Kim JY, Youn YJ, Kim SY, Koh SB, Lee K, et al. Cardiovascular parameters correlated with metabolic syndrome in a rural community cohort of Korea: The ARIRANG study. J Korean Med Sci 2010;25:1045-52.  Back to cited text no. 16
[PUBMED]    
17.
von Bibra H, St John Sutton M. Diastolic dysfunction in diabetes and the metabolic syndrome: Promising potential for diagnosis and prognosis. Diabetologia 2010;53:1033-45.  Back to cited text no. 17
[PUBMED]    
18.
Esmaeilzadeh M, Parsaee M, Maleki M. The role of echocardiography in coronary artery disease and acute myocardial infarction. J Tehran Heart Cent 2013;8:1-13.  Back to cited text no. 18
[PUBMED]    
19.
Reant P, Labrousse L, Lafitte S, Bordachar P, Pillois X, Tariosse L, et al. Experimental validation of circumferential, longitudinal, and radial 2-dimensional strain during dobutamine stress echocardiography in ischemic conditions. J Am Coll Cardiol 2008;51:149-57.  Back to cited text no. 19
[PUBMED]    
20.
Jones CJ, Raposo L, Gibson DG. Functional importance of the long axis dynamics of the human left ventricle. Br Heart J 1990;63:215-20.  Back to cited text no. 20
[PUBMED]    
21.
Reant P, Chasseriaud W, Pillois X, Dijos M, Arsac F, Roudaut R, et al. Early detection of left ventricular systolic dysfunction using two-dimensional speckle tracking strain evaluation in healthy subjects after acute alcohol intoxication. Echocardiography 2012;29:927-32.  Back to cited text no. 21
[PUBMED]    
22.
Carabello BA. Evolution of the study of left ventricular function: Everything old is new again. Circulation 2002;105:2701-3.  Back to cited text no. 22
[PUBMED]    
23.
Holinski S, Knebel F, Heinze G, Konertz W, Baumann G, Borges AC. Noninvasive monitoring of cardiac function in a chronic ischemic heart failure model in the rat: Assessment with tissue Doppler and non-Doppler 2D strain echocardiography. Cardiovasc Ultrasound 2011;9:15.  Back to cited text no. 23
[PUBMED]    
24.
Gaasch WH, Delorey DE, St John Sutton MG, Zile MR. Patterns of structural and functional remodeling of the left ventricle in chronic heart failure. Am J Cardiol 2008;102:459-62.  Back to cited text no. 24
[PUBMED]    
25.
Yu CM, Sanderson JE, Marwick TH, Oh JK. Tissue Doppler imaging a new prognosticator for cardiovascular diseases. J Am Coll Cardiol 2007;49:1903-14.  Back to cited text no. 25
[PUBMED]    
26.
Seo JM, Park TH, Lee DY, Cho YR, Baek HK, Park JS, et al. Subclinical myocardial dysfunction in metabolic syndrome patients without hypertension. J Cardiovasc Ultrasound 2011;19:134-9.  Back to cited text no. 26
[PUBMED]    
27.
Lauer MS, Anderson KM, Kannel WB, Levy D. The impact of obesity on left ventricular mass and geometry. The Framingham heart study. JAMA 1991;266:231-6.  Back to cited text no. 27
[PUBMED]    
28.
Schmieder RE. The role of non-haemodynamic factors of the genesis of LVH. Nephrol Dial Transplant 2005;20:2610-2.  Back to cited text no. 28
[PUBMED]    
29.
Ruberg FL, Chen Z, Hua N, Bigornia S, Guo Z, Hallock K, et al. The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome. Obesity (Silver Spring) 2010;18:1116-21.  Back to cited text no. 29
[PUBMED]    
30.
McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, et al. Cardiac steatosis in diabetes mellitus: A 1H-magnetic resonance spectroscopy study. Circulation 2007;116:1170-5.  Back to cited text no. 30
[PUBMED]    
31.
Alpaydin MS, Aksakal E, Erol MK, Simsek Z, Açikel M, Arslan S, et al. Assessment of regional left ventricular functions by strain and strain rate echocardiography in type II diabetes mellitus patients without microvascular complications. Turk Kardiyol Dern Ars 2011;39:378-84.  Back to cited text no. 31
    
32.
Cottrell C, Kirkpatrick JN. Echocardiographic strain imaging and its use in the clinical setting. Expert Rev Cardiovasc Ther 2010;8:93-102.  Back to cited text no. 32
[PUBMED]    
33.
Ram R, Mickelsen DM, Theodoropoulos C, Blaxall BC. New approaches in small animal echocardiography: Imaging the sounds of silence. Am J Physiol Heart Circ Physiol 2011;301:H1765-80.  Back to cited text no. 33
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]


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